Pharmenta SIPTube® Multipurpose Valve Product Announcement


INTERPHEX Booth #1370



Kim Ball
Pharmenta, Inc.
212 Carnegie Center Suite 206
Princeton, NJ 08540, USA
Phone: (609) 919-6370 or
            (888) 765-7838
Fax: (609) 452-7127

Pharmenta, Inc. Unveils Multi-Purpose SIPTube® Valve

Feed, Sample and Inoculate Deep into the Heart of Your Process and 
Clean and Sterilize in Place Anytime

Princeton, NJ, February 8, 2003: Today Pharmenta, Inc. announced the availability of its multi-purpose SIPTube® valve, which addresses the chronic problems of dead space, stagnation and residue buildup that typically plague sterile access port assemblies. The SIPTube® can replace five traditional devices found in tanks and process pipelines: (1) dip tube, (2) gas sparger, (3) addition device, (4) headspace feed device and (5) fed-batch withdraw/return device. 

"By designing the SIPTube with a deep U-shaped passage and the valve seal located at the tip, adjacent to the process interface, we have created a device that can be completely cleaned and sterilized anytime you like, not just at the beginning of your process," said Douglas Newberg, President of Pharmenta, Inc. "In contrast, other sterile access port assemblies typically consist of valve seals located outside the tank or pipeline, together with a section of blind tube extending into the process. This creates a deadspace that cannot be cleaned or sterilized once your process begins." 

The SIPTube® valve's deep "U" passage design defines a complete cleaning and sterilizing flow path - from the inlet down to the valve seal tip and back up to the outlet. The passage arrangement also creates a vortex flow pattern that effectively scours the valve chamber, and expels condensate. Optional valve body insulation inhibits heat transfer during steam sterilization, allowing you to safely sterilize-in-place anytime you like, even with the most heat-sensitive processes. The elongated, probe-like body of the SIPTube valve easily retrofits in minutes into standard tank and process line ports. It can reach deep into the process to deliver material or capture truly representative samples. 

In-process clean-thru/steam-thru capability offers numerous advantages:


By eliminating loss of flow due to clogging that often occurs with traditional devices, the SIPTube® valve improves process control for gases and metered feeds.


When multiple SIPTube® valves are installed, one unit can be cleaned and sterilized while the other units continue uninterrupted operation, making them ideal for long-term or continuous fed-batch operations.


During a single run, a single SIPTube® valve can be used to feed in media, to inoculate seed, and to feed acids, bases and nutrients. This multi-functional nature makes the SIPTube® valve ideal for smaller, highly instrumented research installations.


Because the SIPTube® valve can be cleaned and sterilized before each sampling episode, and because samples can be drawn from the heart of the process even the first bit of sample material will be pristine, eliminating the need to discard valuable material.

The Pharmenta SIPTube® valve offers a simple, versatile design that provides for improved reliability and fast, easy maintenance. It fits into existing 1.5 inch (37mm) ferrules and has process insertion lengths available up to 16 inches (400mm.) It can be quickly installed in existing portholes, either on top or on the sides of tanks and process piping. It is designed for operation in vertical to horizontal orientations. The SIPTube® valve is available with a variety of biocompatible diaphragm materials, connections, and actuator styles. It is suitable for pharmaceutical, biotech, food and beverage and fine chemical applications.

The Pharmenta SIPTube® valve is available immediately from Pharmenta, Inc. (Phone: 888-765-7838 or 609-750-1251.) Additional information on the product and the company can be found at

Pharmenta's mission is to improve the safety, quality, efficiency and consistency of pharmaceutical products and processes through innovative equipment design. Pharmenta, Inc. is a product division of N. L. Technologies, Ltd. Since 1989, N. L. Technologies has provided regulatory and facility design expertise to pharmaceutical, food and beverage manufacturers around the world. 

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Copyright © 2002-2004 Pharmenta, Inc.  All rights reserved. Pharmenta, the Pharmenta logo, AptiPort, SIPTube, SumpFre and SampleSafe are trademarks or registered trademarks of NL Technologies, Ltd or Pharmenta, Inc..  Pharmenta® products are protected by U.S. and foreign patents and patents pending. Send mail to with questions or comments about this web site.  Last modified: March 29, 2004